Downregulation of ERBB2 signaling
نویسندگان
چکیده
منابع مشابه
Modulation of Erbb2 signaling during development: a threshold level of Erbb2 signaling is required for development.
We have generated a series of Erbb2 cDNA knock-in animals to explore the role of signaling pathways coupled to Erbb2 during development. Although this knock-in allele was hypomorphic, expressing tenfold less Erbb2 protein than wild type, the knock-in animals were healthy. However, a further twofold reduction in Erbb2 levels in hemizygous knock-in animals resulted in perinatal lethality with def...
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INTRODUCTION. Muc4(SMC) is a cell surface glycoprotein composed of two non-covalently bound subunits: an O-glycosylated mucin subunit, ASGP-1, and a mainly N-glycosylated transmembrane subunit ASGP-2 that anchors the molecule to the plasma membrane. The latter serves as an intramembrane ligand for the receptor tyrosine kinase ErbB2 via an EGF-like domain. This interaction occurs shortly after s...
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of a dissertation at the University of Miami. Dissertation supervised by Professor Kermit L. Carraway. No. of pages in text. (78) The membrane mucin Muc4 is a heterodimer, bi-functional glycoprotein complex that is normally expressed in epithelial tissue. Functional studies on the extracellular mucin subunit of Muc4 have shown that it acts to promote anti-adhesion properties by sterically inter...
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In breast cancer, overexpression of ErbB2 or aberrant regulation of survivin, a member of the inhibitor of apoptosis family, is associated with resistance to chemo/hormone therapy and predicts for a poor clinical outcome. A functional link between the two predictive factors has not been previously shown. Here, using genetic and pharmacologic approaches to block ErbB2 signaling, we show that Erb...
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Background: Dysfunction of Schwann cells by diabetes has far-reaching consequences for the structure and function of peripheral nerves. The aim of the present study was to evaluate the effect of aerobic exercise on the Nrg1 / ErbB2 signaling pathway in male rats with diabetic neuropathic pain. Methods: Twenty-four 8-week-old male Wistar rats (weight range 204 ± 11.3 g) were randomly divided in...
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ژورنال
عنوان ژورنال: Reactome - a curated knowledgebase of biological pathways
سال: 2016
ISSN: 1934-1792
DOI: 10.3180/r-hsa-8863795.1